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Recommended adult doses for ‘optimised’ antibiotic dosing

Recommended adult doses for ‘optimised’ antibiotic dosing

Note: many of these agents may require adjustment with significant renal impairment. Seek ID or pharmacy advice if necessary.

Oral agents:

  • Amoxicillin  – 1g tds
  • Augmentin – use ‘boosted augmentin’ (Augmentin 625mg tds + amoxicillin 500mg tds)
  • Ciprofloxacin – 750mg bd
  • Co-trimoxazole – 1440mg bd or 960mg tds

IV agents:

  • Amoxicillin – 1g q6h (standard dose sufficient for ‘I’ when given IV). If patient septic or >100kg use 2g q6h.
  • Augmentin – 1.2g q8h (standard dose sufficient for ‘I’ when given IV). If patient septic or >100kg use ‘boosted IV augmentin’ (Augmentin 1.2g q8h + Amoxicillin 1g q8h)
  • Ceftazidime – 2g q8h
  • Cefepime – 2g q8h
  • Piperacillin-tazobactam (Tazocin) – 4.5g q6h